PIN1 and early-onset autosomal dominant Alzheimer disease: Moreover, Pin1 deregulation has been observed in age-related and neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson disease, frontotemporal dementia, Huntington disease, and amyotrophic lateral sclerosis, where it mediates profoundly different effects, ranging from neuroprotective to neurotoxic (for a review on the topic see [9]).