Moreover, Pin1 deregulation has been observed in age-related and neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson disease, frontotemporal dementia, Huntington disease, and amyotrophic lateral sclerosis, where it mediates profoundly different effects, ranging from neuroprotective to neurotoxic (for a review on the topic see [9]). The gene discussed is PIN1; the disease is neurodegenerative disease.