The results presented here showing the role of nuclear genome-encoded LncRNAs regulating mitochondrial functions are supported by reports showing regulation of mitochondrial functions in podocytes in diabetic nephropathy by nuclear genome-encoded LncRNA taurine-upregulated gene 1 [53], and aberrant NEAT1 expression by mitochondrial stressors [18]. The gene discussed is TUG1; the disease is diabetic kidney disease.