One Asian population-based GWAS identified the following three novel PAD susceptibility loci with genome-wide significance: IPO5/RAP2A (a member of the importin beta family that promotes apolipoprotein A-1 excretion; p = 6.8 × 10−14), EDNRA (p = 5.3 × 10−9), and HDAC9 (p = 8.8 × 10−8). The gene discussed is EDNRA; the disease is peripheral arterial disease.