Univariate logistic regression analysis showed postoperative depression at 1 year was associated with age, allergy status, a higher preoperative hs-CRP level (>2.02 mg/L), and preoperative subjective measurements (ENS6Q, SNOT-25, BDI-II, and BAI scores) (all p < 0.001). The gene discussed is CRP; the disease is Allergy.