Several assumptions have been made to resolve this issue: HL in these patients could be caused by an uncertain impact of the SLC26A4 gene (the presence of yet undetected regulatory or deep-intronic variants and intragenic exon deletions); HL could be the result of digenic inheritance; these patients could be only the coincidental carriers of one pathogenic SLC26A4 variant and, consequently, other factors (other genes or environmental impacts) caused their HL. This evidence concerns the gene SLC26A4 and Hodgkins lymphoma.