ADAM17 and neoplasm: Significant HR values were obtained by Zhang et al.: in their study ADAM17 expression was associated with poor OS (HR = 5.87, 95% CI = 1.59–20.52, p = 0.008), degree of tumor differentiation (p = 0.006), depth of invasion (p < 0.0001), lymph node metastasis (p = 0.02), distant metastasis (p = 0.02) and TNM stage (p = 0.03) [185].