In solid tumors, increased expression of Gal-9 significantly correlated with a lower depth of invasion (OR = 2.80, 95% CI = 1.97–3.96, p < 0.001), an earlier histopathological stage (OR = 3.00, 95% CI = 2.04–4.42, p < 0.001), the absence of lymph node metastasis (OR = 0.47, 95% CI = 0.25–0.89, p = 0.020) and the absence of distant metastasis (OR = 13.85, 95% CI = 3.50–54.76, p < 0.001) [98]. Here, LGALS9 is linked to metastatic malignant neoplasm in the lymph nodes.