In two meta-analyses, increased expression of CD276 in many types of malignant tumors was associated with poor OS (HR = 2.09, 95% CI = 1.60–2.74, p < 0.001; HR = 1.58, 95% CI = 1.32–1.90, p < 0.00001, respectively) [37,39]. This evidence concerns the gene CD276 and cancer.