Among the studies of Gal-9 expression in GC, the most impressive results were shown by Choi et al.; in their study Gal-9 expression was associated with better OS (HR = 0.51, 95% CI = 0.35–0.76, p = 0.001), and the absence of Gal-9 expression was associated with greater depth of infiltration (p < 0.001), lymph node metastasis (p < 0.001), and TNM stage (p < 0.001) [101]. This evidence concerns the gene LGALS9 and metastatic malignant neoplasm in the lymph nodes.