CD274 and metastatic malignant neoplasm in the lymph nodes: For example, in a meta-analysis from Gu et al., an association of PD-L1 expression in GC with such clinical characteristics as the depth of tumor invasion (p = 0.03), lymph node metastasis (p = 0.03), venous invasion (p = 0.0003), Epstein-Barr virus (EBV) infection (p < 0.0001), microsatellite instability (MSI) (p = 0.0001) was found [18].