So, in a meta-analysis by Ni et al. ADAM17 expression was associated with poor OS (HR = 2.04, 95% CI = 1.66–2.50), TNM stage (OR = 4.09, 95% CI = 1.85–9.04) and lymph node metastasis (OR = 3.08, 95% CI = 1.13–8.36) [178]. Here, ADAM17 is linked to metastatic malignant neoplasm in the lymph nodes.