We observed THBS4 to be downregulated in ccRCC patients with LG lesions in the comparison when only considering grade (fc −1.61, p-value 0.02) but upregulated in the HG lesion group (fc 2.43, p-value 0.03) when the sub-cohort of stage 1 patients was evaluated. Here, THBS4 is linked to nonpapillary renal cell carcinoma.