There was no overlap between AD and cortical measures eQTL-regulated gene lists, whereas 24 shared genes were identified for the cognitive performance and cortical structure phenotypes (ARHGAP27, ARL17A, DCC, DEPDC1B, FMNL1, GOSR1, KANSL1, KANSL1-AS1, LINC02210, LOC107984142, LOC339192, LRRC37A, LRRC37A2, MAPT, NDUFAF2, NPIPB9, PLEKHM1, RPS26, SH2B1, SPPL2C, SULT1A1, SULT1A2, SUOX, and TUFM). This evidence concerns the gene SPPL2C and Alzheimer disease.