CHI3L1 and Alzheimer disease: Another recent meta-analysis reported that CSF T-tau, P-tau, Aβ42, NFL, and plasma T-tau were strongly associated with AD, whereas emerging CSF biomarkers such as NSE, VLP-1, HFABP, and YKL-40 were moderately associated, and plasma Aβ42 and Aβ40 were not associated with AD [19].