In the brain, the NADH Dehydrogenase NDUFS3, the glutathione peroxidase enzyme encoded by GPX1, the chromatin-associated protein HMGN4, and tau were upregulated in AD cases, whereas TUFM (Mitochondrial Elongation Factor Tu), LRPPRC (Mitochondrial Leucine-Rich PPR Motif-Containing Protein), and AP3B2 (Adaptor protein complex 3) were downregulated. The gene discussed is MAPT; the disease is Alzheimer disease.