CCND1 and neuroblastoma: Similarly, all cases (44 out of 44) of poorly differentiatedNB showed a diffuse (>70% positive cells) nuclear expression of cyclin D1 (Figure 3), including three cases in which NB84 was lacking (one metastatic subcutaneous case with a previous diagnosis of poorly differentiated NB) (Figure 6) or only focally expressed (two cases histologically and immunohistochemically confirmed in the surgically-resected specimen after chemotherapy).