The 99 AFP—negative intrahepatic primary malignant tumors were divided into HCC group (61 cases) and OM group (38 cases, including 31 cases of intrahepatic cholangiocarcinoma, 2 cases of combined hepatocellular carcinoma and cholangiocarcinoma, 3 cases of lymphoma, 1 case of angiosarcoma and 1 case of spindle cell sarcoma) according to pathological findings. This evidence concerns the gene AFP and angiosarcoma.