CAMP and periodontitis: Despite the fact that this research involved distinctive types of samples (GCF and GTs) and targeted several different HDPs, they all yielded comparable results, suggesting upregulation of HDP in DM2 with periodontitis, with the exception of three studies that revealed downregulation of hCAP18/LL-37 [37], hBD 1 [34] and hBD 1, hBD 2, and hBD 3 [39].