Moreover, Wright et al. developed a probabilistic algorithm (LymphGen) to classify DLBCL into molecular subtypes based on the classifier of Schmitz et al. They identified two additional clusters: cases with TP53 inactivation and those with recurrent mutations in TET2, P2RY8 and SGK1 genes, which were assigned to the A53 and ST2 clusters, respectively, leading to a total of six genetic subtypes [55]. This evidence concerns the gene TP53 and diffuse large B-cell lymphoma.