Although, currently, we have no direct evidence to link the hyperglycemia induced by intermittent hypoxic breathing and hypochloremia [8,9] found in some patients infected with the SARS-CoV-2, earlier studies [10,11] indicate that intermittent hypoxia (IH) exposure disrupts insulin secretion and raises the possibility of a mechanistic link for disturbed glucose regulation in COVID-19; we explored that possibility using our current in vivo and in vitro models. This evidence concerns the gene INS and COVID-19.