The development of allergic asthma involves mainly the synthesis of IgE antibodies against aeroallergens, such as mold, cat and dog dander, mites, etc. The ability to generate high levels of specific IgE antibodies is favored by the genetic susceptibility for such a response and is accompanied by imbalance in the ratio of T-helper 1 (Th-1) to T-helper 2 (Th-2) lymphocytes (Th1/Th2). Here, IGHE is linked to allergic asthma.