Conversely, neither pre-treatment with the α2-blocker Yohimbine nor pre-treatment with the α2-agonist Clonidine alleviated PAN-PDE4 inhibitor-induced hypothermia (Figure 6C), suggesting that α2-adrenoceptor signaling is not involved in the body temperature perturbance produced by PAN-PDE4 inhibitors. Here, PDE4A is linked to polyarteritis nodosa.