PPARA and diabetes mellitus: Western blot analysis demonstrated that PPARα protein levels in the RPE-choroid complex of laser-induced CNV mice (Figure 5A,B) and the retina of STZ-induced rats at 4 weeks after diabetes onset (Figure 5F,G) were significantly higher in the fenofibrate eye drop group compared with vehicle-treated animals at Day 7 of the treatment, indicating that fenofibrate activated PPARα, which upregulated its own expression in the CNV model and STZ-induced diabetic model.