IFP35 and MXA were overexpressed in peripheral blood mononuclear cells (PBMCs) of RA diseased patients, and statistically correlated with the anti-carbamylated proteins antibodies (Anti-CarP) and anti-citrullinated peptide antibodies (ACPA) titers, suggesting a pathogenic involvement of ISGs and confirming the antibodies’ pathogenic role [87]. This evidence concerns the gene IFI35 and rheumatoid arthritis.