This study analyzed the expression of relevant genes (scxa, scxb, runx2a, runx2b, bgp, sp7, col1a2, entpd5a, entpd5b, phex, alpl, and fgf23) during the development of IBs, with the aim to improve our understanding of the molecular mechanisms of IB development. This evidence concerns the gene ALPL and irritable bowel syndrome.