Indeed, daily consumption of red beetroot juice extracts significantly reduced fasting glucose levels in diabetic individuals, as well as in STZ and alloxan-induced diabetic animals, effects that were attributed to increased insulin release (in T1DM), decreased glucose absorptions, stimulated insulin sensitivity, GLUT-2/4 receptor expression, and inhibited hepatic glucose synthesis [25,30,51,52,53]. This evidence concerns the gene INS and type 1 diabetes mellitus.