SERPINI1 and familial encephalopathy with neuroserpin inclusion bodies: Although polymerization and aggregation of neuroserpin are correlated with the so-called serpinopathies, including Familial Encephalopathy with Neuroserpin Inclusion Bodies (FENIB) and up-regulation in AD are more likely, also down-regulation of serine protease inhibitor in multiple sclerosis is discussed [75].