The inhibition of the Wnt signaling pathway is implicated to be involved in an elevated IOP through an increased TM cell stiffness [60] as well as in dysregulation of dendritic outgrowth, axon remodeling, and function of neurons characteristic for glaucoma [61], thus overexpression of IQGAP2, as published for EVO model, appears explainable. Here, IQGAP2 is linked to glaucoma.