VEGFA and cancer: Moreover, the inhibition of loxl2 activity inhibited angiogenesis in part by affecting VEGF signaling in endothelial cells [59] Lgals1/Galectin 1 is one of the members of galectin and plays multifaceted roles in cell adhesion, proliferation, angiogenesis, and immunosuppression, targeting not only a variety of cancer cells, but also vascular endothelial cells and regulatory T cells [60,61].