Furthermore, through the assumption that pSer312-IRS-1 and p-panTyr-IRS-1 are fundamental in Alzheimer’s disease pathogenesis [95], Mullins et al. demonstrated that plasma exosomes enriched for neural origin (L1CAM) correlate with the brain atrophy evaluated with T1-weighted magnetization-prepared rapid gradient-echo (MPRAGE) images [96]. Here, IRS1 is linked to early-onset autosomal dominant Alzheimer disease.