Interestingly, the TgMOB1 proximity interactome, gain-of-function phenotype, and loss-of-function phenotype are more coherent with the functions reported for MOB1 proteins of metazoans in the context of Hippo tumor-suppression signaling, which leads to cell overgrowth and the occurrence of tumors when mutated/depleted [19,69]. The gene discussed is MOB4; the disease is neoplasm.