Since TLR2, TLR3, TLR7, and TLR9 are able to sense EBV infection by monocytes and plasmacytoid dendritic cells, consequently activating the host antiviral response [152,153,165,166], it could be hypothesized that TLR downregulation promoted by HPV infection may disrupt the innate immune recognition of EBV, thus facilitating this infection. This evidence concerns the gene TLR9 and Epstein-Barr virus infection.