The adipocytokines secreted by the adipocytes including adiponectin, leptin, TNF-α, resistin and plasminogen activator 1 (PAI-1) control appetite, insulin sensitivity and inflammation; hence, they play their role in the MAFLD’s pathogenesis and its development to NASH [25]. The gene discussed is RETN; the disease is metabolic dysfunction-associated steatohepatitis.