TNF and Hepatic fibrosis: This is confirmed by our present study in which significantly increased levels of pro-inflammatory mediators TNF-α and NF-κβ, and a significantly decreased level of anti-inflammatory cytokine IL-10 were observed in the liver of the HFD group, as well as elevation in serum lipids and the deposition of collagen fibers, which indicated the presence of liver fibrosis in this group.