In this research, a 3D-full-thickness human skin model of psoriasis (FTRHSP) topically treated with fisetin (10–20 μM) showed suppression of proliferation and induction in the expression of differentiation markers desmoglein-1, TGase-1, filaggrin, involucrin, and KRT10 in the spinous via granular epidermal cell layers, and suppressed the expression of IL-17A, fosfo-p70 ribosomal protein S6 kinase (p-p70S6K), and psoriasin markers related to the activation of mTOR pathway [127]. This evidence concerns the gene IL17A and psoriasis.