Zhang et al. (2020) reported that myocardial ischemia-reperfusion injury (known as oxidative stress condition) via improving mitochondrial fusion/mitophagy and activating the AMPK-OPA1 signaling pathways [43] Wang et al. (2014) reported that AMPK may mediate paraquat-induced myocardial anomalies possibly by regulating the AMPK/mTOR-dependent autophagy [50]. This evidence concerns the gene OPA1 and myocardial ischemia.