Analysis of CAT mRNA in glioma samples of different grades showed that the level of CAT mRNA expression in the tumor correlated inversely with overall survival (OS) in patients (high median CAT expression: OS = 18.0 months; low median CAT expression: OS = 23.4 months; p = 0.0107 by log-rank test) (Figure 1B). The gene discussed is CAT; the disease is central nervous system cancer.