In this study, we provide experimental evidence in a rat cerebral ischemia model of the suppressive effects of the Jak2 inhibitor AG490 on brain injury, apoptosis, oxidative stress, neuroinflammation, hyperglycemia, glucose intolerance, skeletal/hepatic oxidative stress, skeletal/hepatic inflammation, and insulin resistance (Figure 9). Here, JAK2 is linked to brain ischemia.