However, some other studies also show that the early intravenous or intracerebroventricular injection of recombinant IL-6 can improve cerebral ischemia [34,35,36], and the IL-6 signaling component, gp130, may mediate neuroprotective and anti-inflammatory effects against cerebral ischemia [37,38]. The gene discussed is IL6; the disease is Cerebral ischemia.