SURF1 and Leigh syndrome: In LS with SURF1 mutations, intrathecal delivery of adeno-associated viral vector serotype 9 (AAV9)/human SURF1 (hSURF1) was studied in mice and was found effective in improving the biochemical abnormalities induced by SURF1 deficiency, thus showing potential applicability for patients with SURF1-related Leigh syndrome in the future [83].