Interestingly, inhibitors of both COX and LOX pathways convert mouse melanoma to a noninvasive phenotype by downregulating matrix metalloproteinase-2 (MMP-2) [121], an enzyme able to degrade the basement membrane components that can be activated by intracellular ROS/RNS [122]; thus, COX and LOX inhibitors could possibly reduce invasiveness by lowering ROS levels, which in turn would downregulate MMP-2 activity. This evidence concerns the gene MMP2 and melanoma.