Furthermore, the human melanocortin 1 receptor gene (MC1R) wild type signaling, which is responsible for black eumelanin production [97], also promoted DNA repair and ROS scavenging [98]; loss-of-function variants of MC1R associated to pheomelanin production [97] elicited enhanced ROS production and impairment of DNA repair [98], likely contributing to the observed higher rate of melanoma onset. Here, MC1R is linked to melanoma.