For instance, fisetin could reduce melanoma tumor growth in mouse xenografts [186]; honokiol, a NOX1 inhibitor, by reducing cellular ROS levels, decreased the migratory potential of melanoma cells in an in vitro model [187]; and anthocyanins could inhibit proliferation, increase oxidative stress, and reduce mitochondrial membrane potential in melanoma cells but not in normal cells [188]. The gene discussed is NOX1; the disease is melanoma.