In particular, in BRAF V600E mutant melanoma, the MAPK activated pathway leads to hyperphosphorylation of FAM129B, which in turn can compete with Nrf2 for the binding to Keap1; in the absence of its inhibitor Keap1, Nrf2 protein is more stable; thus, its level can increase [155]. Here, KEAP1 is linked to melanoma.