Because activation of the cardiac NMNAT/NAD+/SIR2/FOXO and NMNAT/NAD+/SIR2/PGC-1α pathways was identified to mediate the beneficial effects of endurance training in this animal model, NMN administration can be hypothesized to further potentiate exercise resistance to high-fat diet-induced cardiomyopathy. The gene discussed is SIRT1; the disease is cardiomyopathy.