As shown (Figure 5A), the intracellular amount of SOD-1 in T cells identified two sub-groups of MS-RR subjects—Group 1, with a SOD-1 level similar to healthy donors (MIF fold increase vs. isotype control <10) and Group 2, with a SOD-1 level higher than healthy donors (MIF fold increase vs. isotype control >10). Here, MIF is linked to myeloid sarcoma.