Reduced: brain mt ROS production, ΔΨm change, mt swelling, neuroinflammation (↓p-NFκB, p65/ NFκB p65 ratio), neuronal apoptosis (↓Bax, Bcl2) Enhanced: brain mitochondrial function, p-IR and p-Akt/PKB ser473Function: Both drugs: Enhanced insulin sensitivity, prevented cognitive decline.Only dapagliflozin improved hippocampal synaptic plasticity* the combination of two drugs has better effect than single therapies. Here, BCL2 is linked to Mental deterioration.