Pathogenic mutations leading to autosomal recessive forms of PD have been reported in PRKN (PARK2), PINK1 (PARK6), DJ-1 (PARK7), ATP13A2 (PARK9), and FBXO7 (PARK15), PLA2G6 (PARK14), DNAJC6 (PARK19a,b) SYNJ1 (PARK20), and VPS13C (PARK23) while the autosomal dominant PD genes involved include the SNCA (PARK1), LRRK2 (PARK8), VPS35 (PARK17), and CHCHD2 [13,14,15]. The gene discussed is VPS35; the disease is Parkinson disease.