In diabetic rats, empagliflozin reduced the mortality rate of post-acute myocardial infarction (MI) animals with modification of cardiac metabolomes through SIRT3 upregulation which restores glucose oxidation, increases ketone oxidation, and decreases fatty acid oxidation, enabling the maintenance of the ATP level in the myocardium. The gene discussed is SIRT3; the disease is myocardial infarction.