However, black tea extract, a green tea product, significantly suppressed the release of cytochrome c into cytosol and the protein expression of BAX, caspase-3, caspase-9, and caspase-8, and downregulated the expression of APP and Aβ1-42 by reducing β-secretase and γ-secretase related to the accumulation of amyloid plaque [67]. This evidence concerns the gene CASP8 and amyloidosis.