For instance, constitutive activation of NRF2 resulted in reduced quiescence of long-term hematopoietic stem cells in steady-state hematopoiesis [20], attenuated differentiation of both osteoclasts and osteoblasts [21], severe hyperkeratosis of the esophagus and forestomach in the juvenile [22], and therapeutic resistance and aggressive tumorigenic activity in cancer cells [23,24,25,26]. The gene discussed is NFE2L2; the disease is cancer.