Induction of proinflammatory cytokine genes, such as Il6, and murine inflammatory phenotype models, including experimental autoimmune encephalomyelitis (EAE) and Staphylococcus aureus infection models, were ameliorated by supplementation with chemical NRF2 inducers and genetic activation of Nrf2 [18]. This evidence concerns the gene NFE2L2 and experimental autoimmune encephalomyelitis.