As resveratrol and pterostibenes, the piceatannol and its O-methyl metabolite isorhapontigenin have demonstrated a strong capacity to upregulate SIRT1 mRNA and SIRT1 protein in monocytes cells [282], and have shown a strong effect on miRNAs expression in melanoma and colon cancer [283,284]. The gene discussed is SIRT1; the disease is melanoma.