Moreover, a recent study has demonstrated that formononetin can attenuated triple negative breast cancer cells malignancy by suppressing the lncRNA AFAP1-AS1 expression with an influence on the miR-545-3p/CDK4 and miR-195/Raf-1 axes, which are associated with triple-negative breast cancer chemoresistance [208]. The gene discussed is CDK4; the disease is triple-negative breast carcinoma.