However, it is still debated if SVCT2 expression in cancer cells increases the antioxidant or pro-oxidant effect of AA, because in some cases, AA is co-adjunct in radiotherapy or chemotherapy with carboplatin or paclitaxel, but it also was reported that AA protects MCF-7 breast cancer cells from tamoxifen treatment [26,33]. This evidence concerns the gene SLC23A2 and breast cancer.