MAPT and cancer: The protective effect of Tau was also seen against the toxicity of cancer/chemotherapy drugs, including methotrexate [321], tamoxifen [141,322], methotrexate [323], 5-fluorouracil [324], and cyclophosphamide [325], as well as against immunosuppressive and immunomodulating compounds such as cyclosporine A [326], 7,12-dimethyl benz[a]anthracene [327], endotoxin [328] and LPS [329].