Hepatic iron overload is often associated with hemochromatosis and intriguing results demonstrate that solute carrier family 7, member 11 (Slc7a11), an established ferroptosis-related gene, is up-regulated in iron-overloaded cells, again pointing at ferroptosis as a potential target for the treatment of hemochromatosis-induced tissue injury [90]. Here, SLC7A11 is linked to hemochromatosis type 1.