NFE2L2 and autosomal dominant polycystic kidney disease: Moreover, studies using the autosomal dominant polycystic kidney disease (ADPKD) mice model showed that the genetic deletion of NRF2 enhanced ROS generation and stimulated cyst growth, and to further confirm that NRF2 was activated using pharmacological inhibitors, the data showed that cyst production and disease progression were slowed down in ADPKD mice [38].