Rutin protects the heart against environmental pollutants such as bisphenol and dibutyl phthalate by decreasing the oxidative stress and inflammation through increasing the expression of NRF2 and decreasing the expression of NF-κB, thus modulating the NRF2/NF-κB-signaling pathway in the hearts of rats, and thus, rutin helps in reducing the risk of developing cardiovascular diseases [101]. This evidence concerns the gene NFE2L2 and cardiovascular disorder.