NFE2L2 and diabetic retinopathy: Furthermore, sulforaphane inhibited the NLRP3 inflammasome and prevented the keap1-mediated proteasomal degradation of NRF2 and enhanced the stabilization and nuclear accumulation of NRF2 together with increasing the expression of HO-1 and NAD(P)H: quinone oxidoreductase 1 (NQO1), thereby inhibiting diabetic retinopathy [70].