Natural phytochemicals such as Z-ligustilide and Radix Angelica Sinensis prevent DNA hypermethylation at the NRF2 gene promoter region via suppressing DNA methyltransferase activity, which leads to the re-expression of Nrf2 and its downstream gene targets in TRAMP mice, which underlies the anticancer potential of phytochemicals against prostate cancer [145]. Here, NFE2L2 is linked to Familial prostate cancer.