NFKB1 and cardiovascular disorder: Rutin protects the heart against environmental pollutants such as bisphenol and dibutyl phthalate by decreasing the oxidative stress and inflammation through increasing the expression of NRF2 and decreasing the expression of NF-κB, thus modulating the NRF2/NF-κB-signaling pathway in the hearts of rats, and thus, rutin helps in reducing the risk of developing cardiovascular diseases [101].