NFE2L2 and Parkinson disease: In rotenone-exposed rats, resveratrol downregulated the C/EBP homologous protein (CHOP) and glucose-regulated protein 78, decreased the caspase-3 activity, suppressed the xanthine oxidase activity, and activated the NRF2-signaling pathway in the brain and could thereby be developed as a neuroprotective therapeutic agent for Parkinson’s disease patients [65].