NFE2L2 and endometriosis: Controversially, during endometriosis, there is an increased expression of Nrf2 and its target genes HO-1 and NQO1, together with a decrease in the Keap-1 level, while naringenin effectively modulates the NRF2-mediated-signaling pathway and decreases the invasion of endometrial cells and induces apoptosis [90].