In a mouse model of age-related renal injury, SIRT1/AMPK and PPARα signaling were downregulated, while resveratrol improved the renal function, proteinuria, and glomerulosclerosis by activating NRF2 signaling and activating SIRT1/AMPK and PPARα signaling in the kidney [67]. The gene discussed is PPARA; the disease is glomerulosclerosis.