DNA methyltransferase (DNMT) and histone deacetylase (HDAC) assays on mouse skin epidermal JB6 P+ cells showed that an apigenin dose dependently prevents skin cancer by effectively reversing the hypermethylated status at the promoter region of the NRF2 promoter, thereby enhancing Nrf2 expression and the nuclear translocation of Nrf2 in skin epidermal JB6 P+ cells [75]. This evidence concerns the gene NFE2L2 and skin neoplasm.