In middle cerebral artery occlusion mice and NRF2-deficient mice, the inflammatory proteins TLR4 and NF-kB are increased, while the pharmacological activation of NRF2 using ursolic acid effectively decreases the TLR4 and NF-kB pathway in MCAO-treated rats, suggesting the anti-inflammatory role of ursolic acid in cerebral ischemia [83]. This evidence concerns the gene TLR4 and Cerebral ischemia.