NFE2L2 and age-related macular degeneration: In the age-related macular degeneration mice model, the solid dispersion of quercetin significantly reduced the ROS and malondialdehyde content and restored the SOD, catalase, and glutathione peroxidase activities in both the serum and retinal tissues of WT mice when compared to NRF2 KO mice, suggesting that the solid dispersion of quercetin exhibited protective effects by inhibiting retinal oxidative injury through NRF2 activation in mice [57].