In CCL4-induced liver fibrosis mice, ursolic acid decreased inflammatory markers such as TNF-α, prostaglandin E2, and inducible nitric oxide synthase (iNOS); decreased apoptotic markers like caspase-3; and ultimately, ursolic acid exhibited a hepatoprotective effect against liver fibrosis via the NRF2/ARE-dependent-signaling pathway [86]. This evidence concerns the gene NOS2 and Hepatic fibrosis.