NFE2L2 and Familial prostate cancer: γ-tocopherol, a rich mixture of tocopherols, effectively inhibited hypermethylation at the NRF2 promoter in the prostate of transgenic adenocarcinoma of the mouse prostate (TRAMP) cells and mice, leading to the enhanced expression of NRF2, and prevented prostate cancer in the TRAMP model [143].