In another study, the curcumin analog was shown to inhibit prostate cancer by stimulating NRF2 and its downstream genes via decreasing the expression of Keap1 and, also, decreasing CpG demethylation at the NRF2 promoter by inhibiting DNMT enzymes and HDAC 4 [48]. This evidence concerns the gene NFE2L2 and Familial prostate cancer.