Using in vitro and in vivo acute myeloid leukemia (AML) models, researchers discovered that quercetin induces apoptosis by decreasing the nuclear translocation of NRF2 and its proteasomal degradation, as well as stimulating the downregulation of epigenetic-modifying enzymes HDAC and the upregulation of apoptotic-inducing miRNAs, implying that quercetin epigenetically suppresses AML by targeting the NRf2 pathway. Here, NFE2L2 is linked to acute myeloid leukemia.