AKT1 and central nervous system cancer: There was a tendency to increase the expression of AKT in high-grade gliomas (low-grade 12.5% vs. high-grade 32% gliomas; (p = 0.511); while expression of PI3K was particularly high in low-grade gliomas (low-grade 60% vs. high-grade 50% gliomas; (p = 0.680).