Diverse alterations in the PI3K Class 1A family of proteins have been previously associated with diverse types of cancers [13,21], including gliomas, in which mutations in the catalytic subunit of PI3K (PI3KCA: exons 9 and 20) and mutations in PTEN (exons 5 and 6) are frequently found [22,23]. The gene discussed is PTEN; the disease is glioma.