HLA-B and toxic epidermal necrolysis: We previously reported that common cold medicine (including NSAIDs) related to SJS/TEN with severe ocular involvements was strongly associated with HLA-A*02:06 and significantly associated with HLA-B*44:03 in Japanese patients, and that the HLA allele was insignificant in the SJS/TEN cases without any severe ocular involvement [30].