TCGA-UCEC data indicates that roughly 19% of TP53 mutations in uterine serous carcinoma putatively result in direct TP53 protein truncation through frameshift or splice site alteration, and missense vs. truncating TP53 mutations are not associated with differences in survival or tumor grading (S1B–S1E Fig). Here, TP53 is linked to endometrial serous adenocarcinoma.