Mn has also been linked to Amyotrophic Lateral Sclerosis (ALS), since certain ALS patients have T1-weighted hyperintensity during MRI, a neuroradiological signal associated with Mn overload, as well as an increase in MnSOD levels in motor neurons and genetic variations of two melastatins, TRPM2 and 7. Here, SOD2 is linked to amyotrophic lateral sclerosis.