TRPM2 and amyotrophic lateral sclerosis: Mn has also been linked to Amyotrophic Lateral Sclerosis (ALS), since certain ALS patients have T1-weighted hyperintensity during MRI, a neuroradiological signal associated with Mn overload, as well as an increase in MnSOD levels in motor neurons and genetic variations of two melastatins, TRPM2 and 7.