CXCR1 and malignant glioma: The IC50 of CC-LAAO was found to be seven-times lower than that of OHAP-1, an LAAO isolated from Protobothrops flavoviridis venom, which has exhibited cytotoxic effects against malignant glioma cell lines including C6 (rat), RBR 17T, and U251 cells (human) with IC50 values of 1.9 μg/mL, 2.48 μg/mL, and 2.1 μg/mL, respectively [35].