Given that endothelial cells incubated with uremic serum significantly increased the levels of inflammatory biomarkers of IL-6, IL-8, MCP-1, and PAI-1 [46], we aimed to evaluate the impact of IS on the high glucose endothelial cells to clarify the injury mechanism of DM/CKD patients’ endothelium. The gene discussed is SERPINE1; the disease is diabetes mellitus.