It was reported that the lncRNA NEAT1/miR-34c/NLRP3 axis regulates pyroptosis activation and that the lncRNA MEG3/miR-181a/Egr-1/TLR4 signaling pathway promotes fibrosis and the inflammatory response, both of which mediate the progression of diabetic nephropathy [50,51]. This evidence concerns the gene EGR1 and diabetic kidney disease.