Notably, when compared with individuals with other genetically confirmed subtypes of ataxia evaluated in our clinic, including SPG7-associated spastic ataxia, autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS), common spinocerebellar ataxias (SCAs), cerebellar ataxia with neuropathy and vestibular areflexia syndrome (CANVAS), and AIFM1- associated phenotype among others [29,30,31,32] (and unpublished data) the peripapillary RNFL thickness in the FRDA cohort was significantly thinner. Here, SPG7 is linked to spastic ataxia.