IDH1 and glioblastoma: By comparison III (IDH1-mut versus IDH1-WT glioblastoma) (Figure 1A, comparison III), we discovered 9 metabolites (2-HG, AMP, ATP, creatine, glutamate, taurine, myo-inositol, scyllo-inositol, and sn-glycero-3-phosphocholine) (P < 0.05 and fold change > 1.2) (Tables 1 and 2) and 11 PLS-DA variables with a VIP score > 1 (Figure 4A).