IDH1 and glioma: We investigated distinct comparisons of tissue metabolites derived from NMR analyses, complemented with gene expression data from the RNA-Seq in selected comparisons, to investigate modulations by the IDH1 mutation and histology in the IDH1 mutation status cohort (Figure 1A), and we examined tumor treatments in tissue pairs from newly diagnosed and corresponding progressive glioma with or without treatment between resections in the Longitudinal investigation cohort (Figure 1B).