IDH1 and astrocytoma (excluding glioblastoma): In the IDH1 mutation status cohort (Figure 1A), we compared n = 62 IDH1-mut with n = 39 IDH1-WT samples (Figure 1A, comparison I), n = 26 IDH1-mut astrocytoma with n = 9 IDH1-WT astrocytoma (Figure 1A, comparison II), and n = 7 IDH1-mut glioblastoma with n = 30 IDH1-WT glioblastoma (Figure 1A, comparison III) upon differences in metabolites, pathways, and gene expression profiles.