MSH6 and breast carcinoma: In addition, we also detected a relationship between the high expression level of MSH6 and the poor OS (P=0.00052), PFS (P=0.007), RFS (P=6.5e-14) and DMFS (Distant metastasis-free survival) (P=0.00022) prognosis of breast cancer patients (Supplementary Figure 2E).