In Figure 1A, MSH6’sexpression level in the tumor tissues of HNSC [HPV (Human papillomavirus) +/-] (Head and neck squamous cell carcinoma), LUSC (Lung squamous cell carcinoma), COAD (Colon adenocarcinoma), CHOL (Cholangiocarcinoma), BRCA (Breast invasive carcinoma), ESCA (Esophageal carcinoma), BLCA (Bladder urothelial carcinoma), LIHC (Liver hepatocellular carcinoma), LUAD (Lung adenocarcinoma), STAD (Stomach adenocarcinoma) (P<0.001), READ (Rectum adenocarcinoma) (P<0.01) and GBM (Glioblastoma multiforme (P<0.05) is all higher than that of adjacent normal tissues. The gene discussed is MSH6; the disease is rectum adenocarcinoma.