But the MSH6 expression level in the tumor tissues of KIRP (Kidney renal papillary cell carcinoma), KICH (renal hepatocellular carcinoma), UCEC (Uterine corpus endometrial carcinoma) (P<0.001), THCA (Thyroid carcinoma) and PCPG (Pheochromocytoma and paraganglioma) (P<0.05) is lower than that in adjacent normal tissues. Here, MSH6 is linked to hereditary pheochromocytoma-paraganglioma.